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  1. Home
  3. Biologic Therapy Through Caregivers' Eyes: Insights From A Multicenter Pediatric Rheumatology Survey.
  1. Home
  3. Biologic Therapy Through Caregivers' Eyes: Insights From A Multicenter Pediatric Rheumatology Survey.

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Biologic therapy through caregivers' eyes: insights from a multicenter pediatric rheumatology survey.

Büşra Başer Taşkın1, Ayşenur Doğru Kılınç1, Muhammed Talha Karadoğan2

  • 1Division of Pediatric Rheumatology, Department of Pediatrics, Istanbul University Faculty of Medicine, Istanbul, Türkiye.

Expert Opinion on Biological Therapy
|December 1, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Caregiver experiences with pediatric biologic therapies significantly impact treatment adherence and satisfaction. Integrating structured education and psychosocial support into pediatric rheumatology care is crucial for improving outcomes.

Keywords:
Biologic drugschildrenfamily caregiverrheumatologysurvey

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Area of Science:

  • Pediatric Rheumatology
  • Immunology
  • Patient-Reported Outcomes

Background:

  • Pediatric rheumatic diseases cause significant burdens on children and families.
  • Biologic therapies have transformed management, but caregiver experiences remain understudied.

Purpose of the Study:

  • To explore caregivers' lived experiences with pediatric biologic therapies.
  • To identify factors influencing caregiver perceptions, satisfaction, and support needs.

Main Methods:

  • Cross-sectional survey of 156 primary caregivers of children on biologic disease-modifying antirheumatic drugs (bDMARDs) across three Turkish centers.
  • Questionnaires assessed demographics, knowledge, perceptions, emotions, treatment experiences, satisfaction, and support needs.

Main Results:

  • High satisfaction (98%) with clinic services and perceived child improvement (79%) were reported.
  • Information insufficiency correlated with increased fear (p=0.005). Mothers reported more administration difficulties (p=0.042).
  • Positive perceptions linked to longer treatment duration (p=0.049), while adverse events lowered perceived efficacy (p=0.035).

Conclusions:

  • Caregiver perceptions are vital for treatment adherence and satisfaction in pediatric rheumatology.
  • Structured caregiver education and psychosocial support are essential for family-centered care and improved outcomes.