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Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor
Published on: January 4, 2016
The Centers for Medicare and Medicaid Services and others misunderstand stool testing for colorectal cancer
Gloria D Coronado1, Richard M Hoffman2, Josheili Llavona-Ortiz1
1Epidemiology and Biostatistics, University of Arizona College of Public Health, and University of Arizona Cancer Center, Tucson, AZ, United States.
Abstract:
The May 2021 Centers for Medicare and Medicaid Services (CMS) coverage determination allowed reimbursement for blood-based biomarker tests and other tests for colorectal cancer screening that meet minimum 74% sensitivity and 90% specificity thresholds. However, these performance benchmarks fail to account for the importance of detecting precancerous lesions and the impact of the recommended testing interval on the effectiveness of screening. We review the limitations of the CMS criteria, summarize supporting evidence for stool-based testing and colonoscopy as effective and cost-efficient screening modalities, and offer recommendations to strengthen CMS coverage decisions to better align with public health goals in colorectal cancer prevention.
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