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Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche

Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche

Published on: October 20, 2022

RNArchitects: how hnRNPs shape neuronal landscapes.

Afonso Lourinho^1,2, Marta Silva^1,2, Emanuel Tahiri^1,2,3,4

¹CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.

Brain : a Journal of Neurology

|December 1, 2025

Summary

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are crucial for neuronal RNA regulation, controlling processes vital for brain function. Their dysfunction contributes to neurological disorders, suggesting hnRNPs as potential therapeutic targets.

Keywords:

RNA binding proteins RNA metabolism heterogeneous nuclear ribonucleoproteins neurodegenerative diseases neurodevelopmental disorders neuronal development

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Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

Neurons require precise RNA regulation for specialized functions.
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are key regulators of neuronal RNA metabolism.
hnRNPs control mRNA splicing, stability, transport, and local translation, impacting synaptic plasticity, axonal function, and neurodevelopment.

Purpose of the Study:

To review hnRNP-mediated RNA regulation in the brain.
To examine the role of hnRNPs in neurological diseases.
To explore therapeutic strategies targeting hnRNPs for neurological conditions.

Main Methods:

Literature review of studies on hnRNPs and neurological disorders.
Analysis of hnRNP functions in neuronal RNA metabolism.
Synthesis of current research on hnRNP dysfunction in disease.

Main Results:

hnRNPs are central to coordinating complex RNA processes in neurons.
Dysregulation of hnRNPs is implicated in the pathology of various neurological disorders.
Targeting hnRNPs presents a promising avenue for novel therapeutic interventions.

Conclusions:

hnRNPs are critical for maintaining neuronal function through RNA regulation.
Aberrant hnRNP activity contributes significantly to neurological disease pathogenesis.
Modulating hnRNP function offers potential therapeutic benefits for preserving neuronal health.