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Related Experiment Videos

Facultative polyploidy in endocrine tissues.

P Gilbert, P Pfitzer

    Virchows Archiv. B, Cell Pathology
    |November 3, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Thyroid and adrenal tissues were analyzed for ploidy. Most thyroid cells remained diploid, with no significant differences observed in polyploidy between normal and diseased thyroid tissues, including cancer.

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    Area of Science:

    • Endocrinology
    • Cell Biology
    • Oncology

    Background:

    • Polyploidy, an increase in the set of chromosomes, is a feature of certain differentiated cells.
    • The ploidy status of thyroid and adrenal tissues in various conditions is not fully understood.

    Purpose of the Study:

    • To investigate the ploidy of cell nuclei in normal and pathological thyroid and adrenal tissues.
    • To compare ploidy levels between different thyroid conditions and normal adrenal tissue.

    Main Methods:

    • Analysis of adrenal tissue from 44 autopsies and thyroid tissue from 30 biopsies.
    • Flow and scanning-cytophotometry were used to determine the 4C and 8C nuclear fractions.

    Main Results:

    • Most thyroid cell nuclei were diploid, with no significant differences in the 4C fraction across controls, adenomas, hyperplasias, adenomatous goiters, or thyroid carcinomas.

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  • A significant increase in the 4C fraction was observed in normal adrenal glands of individuals over 50 years of age.
  • One case of adenomatous goiter showed total polyploidization, suggesting facultative polyploidization in the thyroid.

    • Conclusions:

    • The thyroid gland epithelium can facultatively become polyploid, similar to seminal vesicle epithelium, unlike obligatory polyploid organs like the liver and heart.
    • The observed polyploidization in thyroid tissue is not necessarily related to malignancy.