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Updated: Jan 9, 2026

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Reinventing "N" in the A/T/N framework: The case for digital

Rhoda Au1, Zachary Popp2, Spencer Low2

  • 1Department of Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA 02118; Boston University Alzheimer's Disease Research Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA 02118; Departments of Neurology, Medicine, and Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine School of Medicine, Boston, MA, USA 02118; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA 02118.

The Journal of Prevention of Alzheimer'S Disease
|December 1, 2025
PubMed
Summary

Digital measures offer accurate early Alzheimer's disease (AD) detection, complementing amyloid (A) and tau (T) biomarkers. Re-evaluating the A/T/N framework with digital tools is crucial for effective clinical trials and treatments.

Keywords:
A/T/N frameworkAlzheimer’s diseaseBiomarkersClinical meaningfulnessDigital “N”Technology

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