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Updated: Jan 9, 2026

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
Published on: April 24, 2020
A practical slice averaged image method for precise CT size specific dose estimates
Yutaka Dendo1, Keisuke Abe2, Shu Onodera2
1Department of Radiological Technology, Tohoku University Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan. yutaka.dendo.c7@tohoku.ac.jp.
A new method, SSDE slice-averaged image (SSDESAI), simplifies radiation dose estimation in computed tomography (CT). This approach accurately predicts patient radiation dose, offering a practical alternative for clinical settings.
Area of Science:
- Medical Imaging
- Radiology
- Radiation Dosimetry
Background:
- Computed tomography (CT) is essential for diagnosis, but anatomical variations complicate radiation dose estimation.
- Conventional dose indices like CTDIvol and DLP are less effective than size-specific dose estimates (SSDE).
- Calculating water-equivalent diameter (Dw) for each CT slice is laborious and impractical for routine use.
Purpose of the Study:
- To introduce a novel, simplified method for calculating size-specific dose estimates (SSDE) in CT scans.
- To evaluate the accuracy and practicality of the SSDE slice-averaged image (SSDESAI) method compared to existing approaches.
- To assess the SSDESAI method's performance across different anatomical regions.
Main Methods:
- Developed the SSDE slice-averaged image (SSDESAI) method, calculating Dw from a single averaged CT image.
- Retrospectively analyzed CT data from 282 adult patients across chest, abdomen-pelvis, and combined chest-abdomen-pelvis regions.
- Compared SSDESAI with SSDEcenter and mean SSDE using regression analysis and RMSE.
Main Results:
- SSDESAI demonstrated stronger agreement with mean SSDE than SSDEcenter across all scan regions.
- Achieved high R2 values (up to 0.991) and lower root mean square error (RMSE) with SSDESAI.
- The SSDESAI method effectively captures anatomical variability while reducing calculation complexity.
Conclusions:
- SSDESAI offers a more advanced and practical approach for radiation dose prediction in CT.
- This method provides a viable alternative to complex calculations for routine clinical application.
- The findings support the clinical utility of SSDESAI for accurate and efficient dose assessment.
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