Surveillance of bloodstream infections in pediatric patients for 11 years: what was the COVID-19 impact?
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View abstract on PubMed
Summary
This summary is machine-generated.Pediatric bloodstream infections (BSIs) show stable bacterial trends but increased fungal cases and rising antimicrobial resistance post-COVID-19. Continuous antimicrobial resistance surveillance in children is crucial.
Area Of Science
- Pediatric Infectious Diseases
- Microbiology
- Epidemiology
Background
- Bloodstream infections (BSIs) pose significant risks in children, with limited epidemiological data.
- Understanding pediatric BSI trends and antimicrobial resistance is vital for effective treatment.
Purpose Of The Study
- To evaluate the epidemiology of pediatric BSIs from 2013-2023.
- To associate antibacterial consumption with bacterial resistance patterns.
- To compare pre- and post-COVID-19 BSI trends in a Brazilian teaching hospital.
Main Methods
- Retrospective analysis of 15,369 blood cultures from pediatric patients (<18 years).
- Species identification and antimicrobial susceptibility testing using automated systems.
- PCR for carbapenemase-encoding genes in Gram-negative bacilli.
Main Results
- 266 isolates from 224 pediatric patients; Gram-positive cocci (51.9%) predominated, especially in infants.
- Fungal infections emerged post-2015, primarily Candida species in infants.
- Increased Minimum Inhibitory Concentrations (MICs) for meropenem and ceftriaxone observed in 2022-2023.
Conclusions
- The COVID-19 pandemic did not alter overall bacterial BSI trends but correlated with increased fungal infections and rising MICs.
- Findings highlight the need for ongoing antimicrobial resistance (AMR) surveillance in pediatric populations.
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