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Transposons01:24

Transposons

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Transposons, or "jumping genes," are small mobile genetic elements (MGEs) that range from 700 to 40,000 base pairs in length. They are found in all organisms and can move within the same chromosome or transfer to different chromosomes. In some cases, transposons can also jump between different host DNA molecules, such as plasmids or viruses, contributing to genetic variability.Barbara McClintock first discovered these mobile genetic elements in the 1940s while studying maize genetics, and she...
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SILAC Based Proteomic Characterization of Exosomes from HIV-1 Infected Cells
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Decoding cross-talk between Mpox and HIV: insights from transcriptomics and network-based analyses.

Saurav Kumar Mishra1, Tabsum Chhetri1, Sneha Roy1

  • 1Department of Bioinformatics, District-Darjeeling, University of North Bengal, District-Darjeeling, West Bengal, 734013, India.

Virology Journal
|December 2, 2025
PubMed
Summary
This summary is machine-generated.

This study reveals shared gene mechanisms between Human Immunodeficiency Virus (HIV) and Monkeypox virus (Mpox) infections. Identifying common hub genes offers potential for simultaneous therapeutic interventions against both diseases.

Keywords:
Co-expressionCross-talkDEGsHIVMolecular dockingMonkeypoxTranscriptomics

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Area of Science:

  • Virology
  • Genetics
  • Immunology

Background:

  • The Monkeypox virus (MPXV) outbreak poses a significant global health threat, with increasing severity.
  • MPXV infections are notably prevalent in individuals with Human Immunodeficiency Virus (HIV), yet the underlying cross-talk mechanisms remain unexplored.

Purpose of the Study:

  • To investigate the shared molecular mechanisms between HIV and Mpox infections using a network-based approach.
  • To identify common differentially expressed genes (DEGs) and potential therapeutic targets for co-infections.

Main Methods:

  • Utilized network-based methodology to analyze shared DEGs in HIV and Mpox.
  • Performed functional enrichment, co-expression, and transcriptional factor analysis on common DEGs.
  • Conducted gene-disease network analysis and molecular docking to identify potential drug targets.

Main Results:

  • Identified 41 common DEGs between Mpox and HIV datasets.
  • Discovered 8 key hub genes, including SOCS3, NFKBIA, and IFIT1, involved in vital biological functions.
  • Docking analysis confirmed potential drug compound binding to target genes, suggesting therapeutic viability.

Conclusions:

  • Uncovered shared molecular mechanisms between HIV and Mpox through hub gene analysis.
  • Provided novel insights into HIV-Mpox co-infection dynamics.
  • Highlighted potential for simultaneous therapeutic strategies targeting common pathways.