Related Experiment Video
Updated: Jan 6, 2026
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Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
Published on: June 6, 2025
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Investigate the therapeutic differences between temporal interference stimulation and transcranial alternating
Dilinuer Maimaitiaili1, Xiaolong Shi1, Jiali Wu2
1School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Trials
|December 2, 2025
Summary
This study compares temporal interference stimulation (TIS) and transcranial alternating current stimulation (tACS) for treating post-stroke cognitive dysfunction. Researchers will assess cognitive improvements using various tests over two weeks to determine the most effective neuromodulation technique.
Area of Science:
- Neuroscience
- Neuromodulation
- Clinical Trials
Background:
- Electrical neuromodulation therapies like tACS and TIS show promise for cognitive impairments.
- Temporal interference stimulation (TIS) is a novel technique offering deep, non-invasive brain stimulation.
- The comparative efficacy of TIS and tACS for post-stroke cognitive dysfunction (PSCI) remains unclear.
Purpose of the Study:
- To compare the neuromodulation models and clinical performance of TIS and tACS in patients with mild PSCI.
- To evaluate the effectiveness of TIS and tACS in improving cognitive function after stroke.
Main Methods:
- A prospective, single-blind, randomized controlled trial involving 36 participants with mild PSCI.
- Participants were randomly assigned to either TIS (2005 Hz and 2010 Hz, targeting the hippocampus) or tACS (5 Hz, targeting the dorsolateral prefrontal cortex).
- Intervention lasted two weeks, with daily 25-minute sessions, five times per week. Cognitive assessments (MoCA, N-back, DST, STT) and fNIRS were conducted pre- and post-intervention.
Main Results:
- Primary outcome: Montreal Cognitive Assessment (MoCA) scores.
- Secondary outcomes: Performance on N-back task, digital span test (DST), shape trails test (STT), and functional near-infrared spectroscopy (fNIRS) data.
- Data collected at baseline (T1) and post-intervention (T2).
Conclusions:
- This trial will provide critical data on the comparative effectiveness of TIS and tACS for PSCI.
- Findings will help elucidate the distinct neuromodulation mechanisms and clinical outcomes of these two techniques.
- Results may guide the selection of optimal neuromodulation strategies for stroke recovery.
