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Updated: Jun 20, 2026

Controlled Strain of 3D Hydrogels under Live Microscopy Imaging
Published on: December 4, 2020
Dynamic regulation of interfacial adhesion in biomedical hydrogels
Hanjun Sun1, Xinyu Qu1, Qian Wang1
1State Key Laboratory of Flexible Electronics (LoFE) & Institute of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University, Nanjing 211816, China. chelseawq@njtech.edu.cn.
None:
Adhesive hydrogels represent a transformative technology in biomedicine due to their biocompatibility and multifunctionality. While extensive research has focused on improving their adhesion strength, the pursuit of long-term interfacial stability reveals a core conflict: strong adhesion often comes at the expense of easy removal. Dynamically regulating hydrogel adhesion is thus key to personalized medicine, allowing adaptation to complex clinical needs. Designing such systems demands a multifaceted approach that considers the physiological environment, medical requirements, stimulus-induced interfacial rearrangements, and mechanics-driven microstructure reconstruction. The dynamic regulation of hydrogel adhesion is more than a functional upgrade; it represents a paradigm shift for smart materials, from "static design" to "dynamic interaction". This review first introduces the mechanisms of hydrogel adhesion. It then provides an in-depth analysis of strategies for dynamically regulating adhesion at the tissue-hydrogel interface and explores the latest progress and application potential in biomedicine.
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