Exercise and cognition in people with degenerative cerebellar ataxia: a narrative review

Degenerative cerebellar disorders (DCDs) are a group of conditions that involve deterioration of neurons in the cerebellum. People with DCDs (PwDCD) present with multifaceted symptoms across motor (e.g., ataxia, imbalance, impaired gait) and cognitive systems (e.g., altered executive functioning, communication, emotional regulation, and visuospatial skills). The impact of exercise and physical activity on improving cognitive deficits has been investigated in many neurodegenerative conditions including DCDs; however, there is limited evidence for the impact of cognitive impairments in PwDCD on the ability to engage in regular exercise.

This narrative review explores literature related to cognition and exercise in PwDCD, as well as a wider range of neurodegenerative disorders.

We discuss potential cognitive factors contributing to barriers in exercise engagement in PwDCD, as well as highlighting current research regarding the importance of exercise engagement, and ways to overcome barriers to exercise in PwDCD.

While evidence is limited, we highlight the effects of cognition on exercise and suggest future directions to foster multidisciplinary collaboration in DCD management.