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Morganella morganii Urinary Tract Infection in Jordanian Children: Case Series from a Tertiary Hospital
Eyad Altamimi1, Rola Saqan2, Maria AlShurman3
1Department of Pediatric and Neonatology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan. emaltamimi@just.edu.jo.
Background:
Urinary tract infections (UTIs) pose significant risks to children's health, with potential for kidney damage if untreated. Morganella morganii is an uncommon but important pathogen in pediatric UTIs. We aimed to describe the clinical characteristics, risk factors, and antibiotic susceptibility patterns of M. morganii UTIs in Jordanian children.
Materials And Methods:
We conducted a retrospective review of pediatric patients (aged 0-18 years) diagnosed with M. morganii UTIs at King Abdullah University Hospital from 2017 to 2022. Data collected included demographics, clinical presentation, laboratory findings, imaging studies, antimicrobial susceptibility profiles, and treatment offered.
Results:
Nine patients were identified, 77.8% of whom were female, with a median age of 3.35 years (interquartile range, 2-14.5). The most common symptoms were fever (55.6%), malodorous urine (44.4%), and vomiting (22.2%). A high prevalence of underlying urological abnormalities, particularly neurogenic bladder and myelomeningocele (44% each), was noted. Eight cases involved lower UTIs. M. morganii isolates were uniformly sensitive to amikacin, cefepime, and piperacillin-tazobactam but resistant to amoxicillin-clavulanate and nitrofurantoin.
Conclusion:
M. morganii should be considered in pediatric UTIs, especially among children with urinary tract anomalies or catheter use. Awareness of its distinct resistance profile is critical for selecting appropriate empiric therapy.
Insights
Morganella morganii is an uncommon cause of pediatric urinary tract infections (UTIs). This study highlights its clinical features and antibiotic resistance patterns in Jordanian children, emphasizing the need for tailored treatment.
Area of Science:
- Pediatric Infectious Diseases
- Urology
- Microbiology
Background:
- Urinary tract infections (UTIs) in children can lead to severe kidney damage if not promptly treated.
- Morganella morganii is an infrequent but significant pathogen in pediatric UTIs.
- Understanding M. morganii UTIs is crucial for effective management in pediatric populations.
Purpose of the Study:
- To delineate the clinical characteristics of M. morganii UTIs in Jordanian children.
- To identify risk factors associated with these infections.
- To determine the antibiotic susceptibility patterns of M. morganii isolates.
Main Methods:
- A retrospective review of pediatric patients (0-18 years) diagnosed with M. morganii UTIs between 2017 and 2022.
- Data collection included demographics, clinical presentation, laboratory results, imaging, and antimicrobial susceptibility.
- Analysis focused on clinical features, risk factors, and resistance profiles.
Main Results:
- Nine pediatric cases were identified, predominantly in females (77.8%), with a median age of 3.35 years.
- Common symptoms included fever, malodorous urine, and vomiting.
- A significant proportion of patients had underlying urological abnormalities like neurogenic bladder and myelomeningocele (44% each).
- M. morganii showed uniform sensitivity to amikacin, cefepime, and piperacillin-tazobactam, but resistance to amoxicillin-clavulanate and nitrofurantoin.
Conclusions:
- Morganella morganii warrants consideration in pediatric UTIs, particularly in children with urinary tract anomalies or catheter use.
- Knowledge of M. morganii's specific antibiotic resistance profile is essential for guiding empiric therapy decisions.
- This study provides valuable insights into M. morganii UTIs in a Jordanian pediatric cohort.
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