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Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
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Precision Oncology: 2025 in Review

Nicholas Mai1, Nicole Fernandez2,3, Alexander Drilon1

  • 1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Cancer Discovery
|December 2, 2025
PubMed

Insights

Precision oncology advanced in 2025 with new drug approvals and novel therapies targeting difficult pathways. Early cancer detection and artificial intelligence are also transforming personalized cancer care.

Area of Science:

  • Oncology
  • Genomics
  • Pharmacology

Background:

  • Precision oncology has revolutionized cancer treatment by tailoring therapies to individual patient molecular profiles.
  • The field is rapidly evolving, necessitating regular updates on key advancements and emerging trends.

Purpose of the Study:

  • To summarize significant breakthroughs in precision oncology during 2025.
  • To highlight novel therapeutic agents, diagnostic technologies, and computational approaches.

Main Methods:

  • Review of recent clinical trial data and regulatory approvals.
  • Analysis of emerging research in targeted therapies, biomarkers, and diagnostics.
  • Assessment of the impact of artificial intelligence in oncology.

Main Results:

  • Multiple new indications approved for existing precision oncology agents.
  • Promising early data for novel agents targeting classical and previously undruggable pathways.
  • Advancements in antibody-drug conjugates, proteolysis-targeting chimeras, and blood-based cancer detection.
  • Identification of new biomarkers and integration of artificial intelligence for treatment insights.

Conclusions:

  • 2025 marked substantial progress in precision oncology, expanding treatment options and diagnostic capabilities.
  • The integration of novel therapeutic modalities and AI is accelerating the development of personalized cancer care.

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