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Dermal Metastasis From Head and Neck Squamous Cell Carcinoma: Systematic Review and Pooled Analysis
Luke Stanisce1,2, Sabrina R Comess1,2, Raymond Chai1,2
1Department of Otolaryngology-Head & Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
The Laryngoscope
|December 2, 2025
Summary
Dermal metastasis from head and neck squamous cell carcinoma (HNSCC) is rare but indicates aggressive disease. Treatment may improve survival, though further research is needed for effective strategies.
Area of Science:
- Oncology
- Dermatology
- Head and Neck Surgery
Background:
- Dermal metastasis from head and neck squamous cell carcinoma (HNSCC) is a rare complication.
- It is associated with a poor prognosis and limited understanding of clinical characteristics.
- This entity signifies advanced disease progression.
Purpose of the Study:
- To systematically review and characterize clinical associations of HNSCC dermal metastasis.
- To analyze treatment paradigms and their impact on survival outcomes.
- To provide a comprehensive overview of this rare metastatic pattern.
Main Methods:
- Systematic literature search of PubMed, Embase, and Scopus databases.
- Inclusion of 78 studies with 279 cases of HNSCC dermal metastasis.
- Pooled analysis using logistic regression, Kaplan-Meier estimates, and Cox regression.
Main Results:
- Most patients were male with advanced primary HNSCC, predominantly from the oral cavity, larynx, or oropharynx.
- Dermal lesions most commonly occurred on the neck or trunk.
- Median survival was 3.5 months; treatment receipt was associated with a 45% lower hazard of death (HR: 0.55).
Conclusions:
- Dermal metastasis from HNSCC indicates aggressive disease with poor survival outcomes.
- Individualized patient counseling is crucial.
- Further research is warranted to identify effective therapeutic strategies.
