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Artificial intelligence to shed light on the algal dark proteomes
Maxence Plouviez1, Eric Dubreucq2
1Cawthron Institute, 98 Halifax Street East, Nelson, New Zealand.
Patterns (New York, N.Y.)
|December 2, 2025
Abstract
None:
Nelson et al. developed LA⁴SR, a large-scale language-model framework to classify translated open reading frames (ORFeomes) across ten algal phyla. LA⁴SR achieves near-complete protein classification coverage even for algal dark proteomes, where alignment tools often return "no hit." The framework provides a leap forward for high-throughput protein classification in algae and could be a promising tool for better classifying proteins from many organisms.
