Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nuclear Transmutation03:20

Nuclear Transmutation

20.4K
Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed...
20.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Light-regulated reconfigurable MXene-hydrogel gas sensing system via machine learning.

Journal of colloid and interface science·2026
Same author

Associations of nutrient and heavy metal gradients with the diversity, functional traits, and community assembly of marine planktonic ciliates.

Marine environmental research·2026
Same author

Neoadjuvant retlirafusp alfa (anti-PD-L1/TGF-β bifunctional fusion protein) with or without chemotherapy in unresectable stage III non-small cell lung cancer: updated results from the phase 2 TRAILBLAZER trial.

Signal transduction and targeted therapy·2026
Same author

Multimodal voxel-wise of structural and functional brain alterations across the cerebral small vessel disease spectrum.

Neuroradiology·2026
Same author

Structure-property relationships of pyrrolopyrrole Aza-BODIPYs: Substituent effects on NIR absorption and photosensitization.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026
Same author

Sintilimab plus concurrent chemoradiotherapy for treatment of locally advanced small cell lung cancer (SINCE-01): a phase II clinical trial.

Signal transduction and targeted therapy·2026

Related Experiment Video

Updated: Jan 9, 2026

Neutron Radiography and Computed Tomography of Biological Systems at the Oak Ridge National Laboratory's High Flux Isotope Reactor
10:24

Neutron Radiography and Computed Tomography of Biological Systems at the Oak Ridge National Laboratory's High Flux Isotope Reactor

Published on: May 7, 2021

2.7K

State-of-the-art boron clusters for boron neutron-capture therapy.

Weiyao Wang1, Enze Zhang1, Jiaojiao Shan2

  • 1School of Pharmaceutical Sciences & Institute of Materia Medica, National Key Laboratory of Advanced Drug Delivery System, Key Laboratory for Biotechnology Drugs of National Health Commission (Shandong Academy of Medical Sciences), Key Lab for Rare & Uncommon Diseases of Shandong Province, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, China.

Theranostics
|December 2, 2025
PubMed
Summary
This summary is machine-generated.

Boron neutron-capture therapy (BNCT) shows promise for cancer treatment. Novel boron clusters offer improved targeting and efficacy for next-generation BNCT drugs, addressing limitations of current therapies.

Keywords:
Accelerator devicesAnti-cancer mechanismBNCTBoron clustersTargeted drugs delivery

More Related Videos

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.9K
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.1K

Related Experiment Videos

Last Updated: Jan 9, 2026

Neutron Radiography and Computed Tomography of Biological Systems at the Oak Ridge National Laboratory's High Flux Isotope Reactor
10:24

Neutron Radiography and Computed Tomography of Biological Systems at the Oak Ridge National Laboratory's High Flux Isotope Reactor

Published on: May 7, 2021

2.7K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.9K
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.1K

Area of Science:

  • Interdisciplinary science
  • Medicinal chemistry
  • Biomedicine

Background:

  • Boron neutron-capture therapy (BNCT) is a precise radiotherapy targeting cancer cells via neutron capture by boron-10.
  • Current boron drugs (e.g., BPA) have limitations including poor targeting and low efficacy.
  • Boron clusters, with their stability and unique structures, are promising candidates for advanced BNCT agents.

Purpose of the Study:

  • To review strategies for constructing and functionalizing boron clusters for BNCT.
  • To explore the structure-function relationships of boron clusters in precision synthesis and biomedicine.
  • To highlight advancements in BNCT visual evaluation, mechanisms, and neutron accelerator devices.

Main Methods:

  • Summarizing new strategies for boron cluster construction and multi-level structures.
  • Describing chemical functionalization methods for clinical applications.
  • Reviewing applications of functionalized boron cluster derivatives and their cross-disciplinary value.

Main Results:

  • Boron clusters offer a framework for rational drug design due to their stability and structure.
  • Functionalized boron clusters show potential for improved BNCT efficacy and applicability.
  • Advancements in BNCT evaluation, mechanisms, and equipment are discussed.

Conclusions:

  • Development of novel boron drugs based on functional boron clusters is crucial for overcoming BNCT challenges.
  • This review provides insights into designing new BNCT drugs, equipment, and treatments.
  • Boron clusters hold significant cross-disciplinary value in precision synthesis, biomedicine, and materials science.