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Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis

Ying Dong1, Hong-Song Ge1, Rui-Xue Chang2

  • 1Department of Dermatology, Anhui Provincial Children's Hospital, Hefei, Anhui, China.

Frontiers in Genetics
|December 2, 2025
PubMed
Summary

This study identified seven key genes associated with psoriasis susceptibility, predominantly expressed in CD4+ T cells. These findings offer potential biomarkers and therapeutic targets for managing this chronic skin condition.

Keywords:
CD4 T cellsMendelian randomizationgenespsoriasissingle-cell RNA sequencing

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