Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
7.6K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

6.3K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.3K
Cancer Survival Analysis01:21

Cancer Survival Analysis

630
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
630
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

850
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
850
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

6.9K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.9K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

412
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
412

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantifying treatment-related travel burden and its association with mortality in pediatric cancer: An analysis of state cancer registry data.

Cancer epidemiology·2026
Same author

Polarisome core component FgPea2 regulates FgBoi2-mediated polarized growth, pathogenicity and environmental stress in Fusarium graminearum.

Stress biology·2026
Same author

Genetic diversity analysis and core collection construction of Macadamia spp. from Yunnan using fourfold degenerate SNP sites.

BMC plant biology·2026
Same author

Case Report: Extracorporeal membrane oxygenation in acute coronary syndrome: a rare case of massive left ventricular thrombus.

Frontiers in cardiovascular medicine·2026
Same author

Exploring the Differences in Alkaloids of Fritillariae Thunbergii Bulbus From Different Regions Using Liquid Chromatography-Mass Spectrometry and Chemometrics.

Chemistry & biodiversity·2026
Same author

A comprehensive narrative review of <i>Epimedium</i> and its bioactive compounds in respiratory diseases.

Journal of pharmaceutical analysis·2026
Same journal

Correction to: Home dampness and molds and occurrence of respiratory tract infections in the first 27 years of life: the Espoo Cohort Study.

American journal of epidemiology·2026
Same journal

A SIMPLE AND POWERFUL TEST OF VACCINE WANING.

American journal of epidemiology·2026
Same journal

Association Between maternal body mass index, offspring growth and pubertal timing: results from a longitudinal birth cohort study.

American journal of epidemiology·2026
Same journal

Correction to: Developing a novel algorithm to identify incident and prevalent dementia in Medicare claims-the ARIC Study.

American journal of epidemiology·2026
Same journal

RE: advancing observational research on arts and health: theory-informed approaches using the RADIANCE framework.

American journal of epidemiology·2026
Same journal

Maternal Cesarean Section and Offspring ASD or ADHD Risk: A Nurses' Health Study II Analysis.

American journal of epidemiology·2026
See all related articles

Related Experiment Video

Updated: Jan 9, 2026

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
09:36

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

30.2K

Calibrated Dietary Patterns and Cancer Risk in the Women's Health Initiative Cohorts.

Xiaochen Zhang1,2, Sowmya Vasan3, Cheng Zheng4

  • 1Public Health Sciences Division, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA, United States, 98109.

American Journal of Epidemiology
|December 2, 2025
PubMed
Summary
This summary is machine-generated.

Metabolomics improved diet assessment, strengthening links between healthy eating patterns and reduced cancer risk. This approach helps overcome self-reported diet inaccuracies in large studies like the Women's Health Initiative.

Keywords:
cancer riskdietary patternsmetabolomicspostmenopausal women

More Related Videos

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
09:10

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents

Published on: November 1, 2019

11.4K
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

628

Related Experiment Videos

Last Updated: Jan 9, 2026

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
09:36

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

30.2K
Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
09:10

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents

Published on: November 1, 2019

11.4K
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

628

Area of Science:

  • Nutritional epidemiology
  • Metabolomics
  • Cancer research

Background:

  • Dietary assessment relies on self-report, prone to significant measurement error.
  • Dietary indices like the Healthy Eating Index 2010 (HEI-2010) and Alternative Healthy Eating Index 2010 (AHEI-2010) are used to quantify diet quality.
  • Accurate diet assessment is crucial for understanding diet-disease relationships, particularly cancer risk.

Purpose of the Study:

  • To develop and validate calibration equations using metabolomics to correct for dietary measurement error.
  • To examine the associations between metabolomic-calibrated dietary patterns and cancer risk within the Women's Health Initiative (WHI) cohort.
  • To assess whether metabolomic calibration enhances the detection of diet-cancer associations.

Main Methods:

  • Calibration equations were developed by regressing HEI-2010 and AHEI-2010 scores on metabolites derived from fasting blood and 24-hour urine samples in a WHI Feeding study.
  • Metabolomic signatures were generated from participants in the WHI Feeding and Observational Studies.
  • Metabolomic-calibrated dietary patterns were estimated using data from 24-hour dietary recalls, Food Frequency Questionnaires (FFQ), and 4-Day Food Records (4DFR).
  • Cox regression models were used to estimate cancer risk associated with metabolomic-calibrated dietary patterns, with a median follow-up of 15.8 years.

Main Results:

  • Calibration equations achieved adjusted R-squared values ranging from 48.8% to 62.6% for different dietary assessment methods.
  • Uncalibrated HEI-2010 showed associations with reduced risk for colorectal, lung, bladder, and total invasive cancers.
  • Metabolomic calibration strengthened the association between higher HEI-2010 scores and reduced risk of lung and total invasive cancers.
  • Calibration improved the precision and magnitude of diet-cancer risk associations.

Conclusions:

  • Metabolomics-based calibration effectively addresses measurement error in self-reported dietary data.
  • This approach can strengthen the observed associations between healthy dietary patterns and reduced cancer risk.
  • Metabolomic calibration offers a promising strategy for more accurate nutritional epidemiology and cancer prevention research.