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Updated: Jan 9, 2026

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
Published on: July 25, 2019
The Role of Ubiquitination Regulation in Nasopharyngeal Carcinoma
Zhenyu Yan1,2, Xiang Cao1, Chengxian Ma3
1The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China.
Abstract:
Nasopharyngeal carcinoma (NPC) is one of the most common malignant head and neck tumors. Despite being sensitive to radiation, the prognosis of some NPC patients remains unoptimistic due to the resistance to therapeutic approaches. Ubiquitination is a crucial post-translational modification of proteins, and is key to maintaining protein homeostasis in vivo. Studies have shown that ubiquitination modification can regulate cell proliferation, apoptosis, and other processes, thereby affecting the development of NPC. In this review, we summarize the research on ubiquitination regulation in NPC, aiming to explore new therapeutic targets and provide feasible solutions to improve the prognosis of NPC patients.
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