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Updated: Jun 19, 2026
12:13
Ex Situ Normothermic Machine Perfusion of Donor Livers
Published on: May 26, 2015
12.1K
Use of Machine Perfusion in Pediatric Liver Transplantation
Ioannis A Ziogas1, Emmanouil Giorgakis2, Dor Yoeli1
1Division of Transplant Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora, Colorado, USA.
Pediatric Transplantation
|December 2, 2025
Summary
Machine perfusion (MP) supports pediatric liver transplantation (LT) in sicker children, utilizing split grafts and enabling longer organ preservation. This method expands donor options without affecting patient or graft survival rates.
Area of Science:
- Hepatology
- Transplantation Surgery
- Pediatric Critical Care
Background:
- Machine perfusion (MP) is a technique to preserve donor organs, potentially expanding the donor pool for liver transplantation (LT).
- Its application in pediatric LT remains limited, necessitating comparative studies.
Purpose of the Study:
- To compare the characteristics and outcomes of pediatric LT recipients who received organs preserved with MP versus those who did not.
- To evaluate the safety and efficacy of MP in the context of pediatric liver transplantation.
Main Methods:
- Retrospective analysis of pediatric LT recipients (<18 years) from January 1, 2016, to December 31, 2024, using United Network for Organ Sharing data.
- Comparison between the MP group and all non-MP recipients, as well as propensity score-matched non-MP recipients.
Main Results:
- MP recipients had higher MELD/PELD scores and were more likely to receive split grafts from older donors with longer preservation times.
- No significant differences in patient or graft survival were observed between MP and non-MP groups.
- MP recipients showed a higher incidence of ascites compared to matched non-MP recipients.
Conclusions:
- Machine perfusion is a viable strategy for pediatric LT, particularly for sicker children requiring split grafts.
- MP facilitates extended organ preservation and broader allocation radii without compromising survival outcomes.
- Further research may explore optimizing MP protocols for pediatric liver grafts.
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