Related Experiment Video
Updated: Jan 9, 2026
Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
Published on: August 26, 2014
Intestinal Ultrasound Transmural Healing Was Associated With Improved Long-Term Outcomes Among Patients With
Clara Yzet1, Amélie Plancke2, Franck Brazier1
1Gastroenterology Unit, Amiens University Hospital, Amiens, France.
Background:
STRIDE II guidelines recognise endoscopic healing as a main therapeutic target in Crohn's disease (CD). Nevertheless, transmural healing (TH) could reduce the risk of long-term complications.
Aim:
To assess the impact of intestinal ultrasound (IUS) TH on CD long-term among patients with endoscopic healing.
Method:
We conducted a prospective study of consecutive patients with CD who underwent colonoscopy with endoscopic healing (CDEIS < 4) and IUS. IUS TH was defined by a bowel wall thickness < 3 mm without colour Doppler signal. The primary endpoint was CD relapse (drug intensification, initiation of steroid, CD-related hospitalization or surgery, luminal stricture/fistula or perianal CD).
Results:
We included 93 patients. IUS TH was observed in 73%. No difference in median IBD-risk score was observed among patients with and without IUS TH (22 (IQR 7-41) vs. 30 (IQR 13-55); p = 0.15). After a median follow-up of 22.5 months (IQR 19.3-23.7), the cumulative risk of relapse was significantly lower among patients with IUS healing (17% vs. 48%; p = 0.007). The benefit of TH remained when considering only patients with complete endoscopic healing (CDEIS = 0) (12-month relapse rate, 2% vs. 33%; p = 0.03). The risk of CD-related hospitalization (3% vs. 16%; p = 0.04) and perianal CD (3% vs. 16%; p = 0.04) were significantly lower among patients with IUS healing. In multivariate analysis, the absence of TH remained the only independent factor associated with CD relapse (hazard ratio 2.6 (1.1-6.2); p = 0.03).
Conclusion:
IUS TH was associated with improved long-term outcomes with lower risks of CD relapse, hospitalization, and perianal CD.
More Related Videos
04:05Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy
Published on: August 22, 2025
07:44Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction
Published on: March 25, 2022
Related Concept Videos
01:25Ultrasound II: Endoscopic Ultrasound and FibroScan
Endoscopic Ultrasound (EUS):
01:26Peptic Ulcer Disease IV: Management
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
01:21Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
01:26Endoscopic Procedures V: ERCP
Patient...
01:25Peptic Ulcer Disease V: Surgical Management and Nursing Care
Surgical Interventions for Peptic Ulcer Disease