Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The combination of <i>EWSR1-FLI1</i> and loss of one <i>EWSR1</i> allele leads to the induction of trisomy 8.

bioRxiv : the preprint server for biology·2026
Same author

Early Effects of the Serious Accidents Punishment Act on Occupational Health Outcomes in Korea: A Nationwide Difference-in-Differences Study (2017-2023).

American journal of industrial medicine·2026
Same author

Overestimated body image distortion and suicidal behaviors among South Korean adolescents: a gender-stratified analysis using Korea Youth Risk Behavior Survey data (2019-24).

Journal of public health (Oxford, England)·2026
Same author

A peak-oriented diffusion model for high-fidelity electrocardiogram reconstruction from photoplethysmogram: development and usability study.

BioData mining·2026
Same author

Ewsr1a Regulates the Development of the Axial Skeleton in Zebrafish.

Zebrafish·2026
Same author

Identifying sorafenib benefit among patients with hepatocellular carcinoma: A transcriptomic and genomic approach.

JHEP reports : innovation in hepatology·2026
Same journal

Bioinspired Artificial Bioenergetic Organelles: Design Principles, Nanofabrication and Therapeutic Translation.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Advanced Electrolyte Materials Design for High-Energy Lithium Metal Batteries Beyond 500 Wh Kg<sup>-1</sup>.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Hydrophilic-Stable Nucleoside-Based Hydrogen-Bonded Organic Frameworks (N-HOF) for Therapeutic Bacterial Hybrid Systems.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Lanthanide-Bridged Dual-Atom Catalysts for Efficient Chlorine Electrosynthesis.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Composite Liquid Marble Templated Millimetric Capsule With Tunable Rigidity, Porosity, and Thermal Reconfigurability Toward 3D Cell Culture.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Bias-Triggered Conductivity Relaxation (BCR): A Unique Tool to Simultaneously Investigate Thermodynamics, Kinetics, and Electrostatic Effects of Oxygen Reactions in MIEC Thin Films.

Advanced materials (Deerfield Beach, Fla.)·2026
See all related articles

Related Experiment Video

Updated: Jan 9, 2026

Computer Numerical Control Micromilling of a Microfluidic Acrylic Device with a Staggered Restriction for Magnetic Nanoparticle-Based Immunoassays
09:58

Computer Numerical Control Micromilling of a Microfluidic Acrylic Device with a Staggered Restriction for Magnetic Nanoparticle-Based Immunoassays

Published on: June 23, 2022

2.5K

Remote-Controllable Immune-Priming Spot Formation Via Nanocomplexed Hydrogel-Assisted Histotripsy: Immunoasis.

Sung Hoon Kim1, Wonseok Choi2, Yurim Kim1,3

  • 1Biomaterials Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.

Advanced Materials (Deerfield Beach, Fla.)
|December 2, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces Immunoasis, a novel immunotherapy that converts "immune desert" tumors into active sites. It uses hydrogels and ultrasound to deliver cancer vaccines locally, enhancing T cell responses and improving treatment efficacy.

Keywords:
in situ cancer vaccineinjectable hydrogelmulti‐targetablenanocomplexespatient‐favorable

More Related Videos

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization
10:06

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization

Published on: September 2, 2022

2.2K
Electrowetting-based Digital Microfluidics Platform for Automated Enzyme-linked Immunosorbent Assay
08:22

Electrowetting-based Digital Microfluidics Platform for Automated Enzyme-linked Immunosorbent Assay

Published on: February 23, 2020

10.1K

Related Experiment Videos

Last Updated: Jan 9, 2026

Computer Numerical Control Micromilling of a Microfluidic Acrylic Device with a Staggered Restriction for Magnetic Nanoparticle-Based Immunoassays
09:58

Computer Numerical Control Micromilling of a Microfluidic Acrylic Device with a Staggered Restriction for Magnetic Nanoparticle-Based Immunoassays

Published on: June 23, 2022

2.5K
Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization
10:06

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization

Published on: September 2, 2022

2.2K
Electrowetting-based Digital Microfluidics Platform for Automated Enzyme-linked Immunosorbent Assay
08:22

Electrowetting-based Digital Microfluidics Platform for Automated Enzyme-linked Immunosorbent Assay

Published on: February 23, 2020

10.1K

Area of Science:

  • Oncology
  • Immunology
  • Biomedical Engineering

Background:

  • Immunotherapy shows promise for durable cancer treatment but is limited by immunosuppressive tumor microenvironments known as "immune deserts."
  • These "immune deserts" are characterized by low T cell infiltration and suppressive myeloid cells, hindering effective antitumor responses.
  • Current strategies like cancer vaccines face challenges with systemic administration, leading to adverse effects and off-target immune activation.

Purpose of the Study:

  • To develop a spatiotemporally controllable immunotherapeutic system, termed "Immunoasis," to overcome the limitations of treating "immune desert" tumors.
  • To investigate the potential of combining injectable, adjuvant-loaded hydrogels with externally triggered boiling histotripsy for localized cancer immunotherapy.
  • To transform immunosuppressive tumor microenvironments into immune-responsive niches, thereby enhancing antitumor immunity and therapeutic efficacy.

Main Methods:

  • Development of an injectable hydrogel system loaded with immunostimulatory adjuvants for prolonged local retention.
  • Utilizing externally triggered boiling histotripsy to disrupt tumor tissues and convert the hydrogel into antigen- and adjuvant-enriched nanocomplexes in situ.
  • Evaluating the localized activation of immune responses, including enhanced antigen presentation and T cell recruitment at the tumor site.

Main Results:

  • The Immunoasis platform successfully enabled prolonged local retention of immunostimulatory payloads.
  • Histotripsy-induced disruption of tumor tissues resulted in the in situ formation of nanocomplexes, effectively delivering antigens and adjuvants.
  • Localized immune activation was enhanced, leading to improved antigen presentation and increased T cell recruitment within the tumor microenvironment.

Conclusions:

  • Immunoasis effectively transforms "immune desert" tumors into immune-responsive microenvironments by establishing localized immune-priming niches.
  • The combination of hydrogels and controlled histotripsy offers a tunable and personalized approach to cancer immunotherapy.
  • This novel platform demonstrates significant potential for enhancing antitumor immunity and improving therapeutic outcomes in challenging tumor types.