Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.2K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.2K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

934
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
934
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

1.3K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.3K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

382
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
382
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.2K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.1K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between probiotic prescriptions and the incidence of primary open-angle glaucoma in patients with documented dry eye.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
Same author

Finerenone Exposure and Ischemic Stroke in Patients with Type 2 Diabetes and Chronic Kidney Disease: A Propensity Score-Matched Cohort Study.

Clinical medicine (London, England)·2026
Same author

Association of Tirzepatide versus Glucagon-Like Peptide-1 Receptor Agonists with Incident Glaucoma in Patients with Type 2 Diabetes: A Retrospective Cohort Study.

Ophthalmology science·2026
Same author

GLP-1 Receptor Agonists and Age-related Macular Degeneration Risk in Diabetes or Non-diabetic Obesity: A Retrospective Cohort Study.

The American journal of medicine·2026
Same author

Smoking-associated modulation of gut microbiota shapes response to immune checkpoint inhibitors in non-small cell lung cancer.

Cancer immunology, immunotherapy : CII·2026
Same author

Gut microbiome signatures discriminate deep vein thrombosis through machine learning and metabolic analysis.

Scientific reports·2026
Same journal

Dual-Hit Myopia Mechanism Unveiled by Multi-Omics: Opn1mw Deficiency Primed the Retina for Exaggerated Response to Environmental Defocus.

Investigative ophthalmology & visual science·2026
Same journal

Psychometric Performance of Children With Amblyopia During a Tablet-Based Adaptive Visual Acuity Assessment.

Investigative ophthalmology & visual science·2026
Same journal

The Molecular Basis of Ocular Aging: Mechanisms, Pathologies, and Emerging Therapeutics.

Investigative ophthalmology & visual science·2026
Same journal

Sensory Eye Dominance Remains Stable Across Binocular Combination and Rivalry in Normal and Anisometropic Amblyopic Vision.

Investigative ophthalmology & visual science·2026
Same journal

Exosome-Associated Gene Network and the Role of SPP1 in Herpes Stromal Keratitis and the Therapeutic Modulation by Ursolic Acid.

Investigative ophthalmology & visual science·2026
Same journal

Nonlinear Associations of Estimated Glucose Disposal Rate With Incident Age-Related Eye Diseases: Implications for Metabolic Risk Stratification.

Investigative ophthalmology & visual science·2026
See all related articles

Related Experiment Video

Updated: Jan 9, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.8K

Association Between Statin Use and Glaucoma Risk: A Population-Based Study.

Ssu-Yu Pan1,2, Chien-Hsiang Weng3,4, Peng-Tai Tien5,6

  • 1School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Investigative Ophthalmology & Visual Science
|December 2, 2025
PubMed
Summary
This summary is machine-generated.

Statin use, especially atorvastatin and rosuvastatin, is linked to higher risks of ocular hypertension and primary open-angle glaucoma (POAG) in hyperlipidemia patients. Longer statin use correlates with increased glaucoma risk.

More Related Videos

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.8K
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.5K

Related Experiment Videos

Last Updated: Jan 9, 2026

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.8K
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.8K
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.5K

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Public Health

Background:

  • Hyperlipidemia is a common condition requiring lipid-lowering therapy.
  • Glaucoma encompasses a group of optic neuropathies that can lead to vision loss.
  • Understanding medication side effects is crucial for patient safety and treatment efficacy.

Purpose of the Study:

  • To investigate the association between statin use and the risk of developing glaucoma.
  • To examine specific statin types and durations of use in relation to glaucoma risk.
  • To explore the impact of other lipid-lowering drugs, such as fibrates, on glaucoma risk.

Main Methods:

  • A nationwide nested case-control study utilized data from the Taiwan National Health Insurance Research Database (2009-2020).
  • Adults with hyperlipidemia were included, with cases defined by new diagnoses of ocular hypertension, primary open-angle glaucoma (POAG), or normal tension glaucoma (NTG).
  • Logistic regression models analyzed the association between cholesterol-lowering medication exposure (statins, fibrates) and glaucoma risk.

Main Results:

  • Statin users showed significantly higher risks of ocular hypertension (aOR=1.12) and POAG (aOR=1.07) compared to non-users.
  • Atorvastatin and rosuvastatin were particularly associated with increased risks; longer statin use duration correlated with higher glaucoma risk.
  • Fibrate use was also linked to increased risks of ocular hypertension (aOR=1.05) and POAG (aOR=1.09).

Conclusions:

  • Statin therapy, specifically atorvastatin and rosuvastatin, is associated with elevated risks of ocular hypertension and POAG in hyperlipidemia patients.
  • The risk of glaucoma appears to escalate with prolonged statin treatment duration.
  • Healthcare providers should consider these findings when prescribing lipid-lowering medications.