Resolution of Lichen Simplex Chronicus With Nemolizumab: A Case Report

Lichen simplex chronicus is a debilitating condition characterized by lichenified skin secondary to intractable itch. Lichen simplex chronicus is challenging to treat, with current treatment options, such as topical calcineurin inhibitors, gabapentinoids, and dupilumab, commonly being ineffective, leaving patients with worsening symptoms and poor quality of life.

We report a case of lichen simplex chronicus in the setting of neuropathic pruritus successfully treated with nemolizumab in a 52-year-old woman. The patient did not report any side effects but reported significant improvement in quality of life.

Lichen simplex chronicus has a significant impairment on quality of life, as it has been linked to anxiety, depression, and poor sleep, underscoring the importance of proper disease management. Current treatment regimens for lichen simplex chronicus are often ineffective. Our observation suggests that nemolizumab may be effective in managing lichen simplex chronicus; larger studies are warranted to confirm these findings.