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Updated: Jan 6, 2026

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
Published on: August 2, 2022
[Patients with brain metastases : The role of neurosurgery]
Stephanie T Jünger1, Tommaso Araceli2,3, Stefan Grau4,5
1Zentrum für Neurochirurgie, Abteilung für Allgemeine Neurochirurgie, Medizinische Fakultät und Universitätsklinikum Köln, Universität zu Köln, Kerpener Str. 62, 50937, Köln, Deutschland. stephanie.juenger@uk-koeln.de.
Abstract:
Brain metastases are the most frequent intracranial tumor entity and in most cases are a sign of advanced systemic cancer. Advances in neurosurgery, pathology, radiotherapy and oncology, especially with the introduction of immune and targeted systemic treatment, have significantly improved the prognosis for patients with brain metastases in recent years. Neurosurgical treatment plays a key role in symptom relief, reduction of the tumor burden and tissue acquisition for molecular analysis to enable patients to undergo postoperative radiotherapy and systemic therapy. The creation of an optimal patient-oriented treatment concept requires close interdisciplinary coordination and structured follow-up to make individualized and evidence-based treatment decisions.

