Epidemiological and clinical profile of sickle cell disease in a series of Moroccan children
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View abstract on PubMed
Summary
This summary is machine-generated.Sickle cell disease (SCD) significantly impacts Moroccan children, with rural prevalence and consanguinity noted. Higher fetal hemoglobin offers protection, underscoring the need for national management strategies.
Area Of Science
- Pediatrics
- Hematology
- Genetics
Background
- Sickle cell disease (SCD) is a prevalent global genetic disorder.
- It stems from abnormal hemoglobin (HbS) in red blood cells, causing severe complications.
- Understanding SCD's characteristics in specific populations is crucial for targeted interventions.
Purpose Of The Study
- To delineate the epidemiological and clinical features of SCD in Moroccan children.
- To identify distinct clinical profiles and associated factors within this cohort.
Main Methods
- A prospective descriptive study involving 194 Moroccan children (97 SCD patients, 97 controls).
- Data collection via medical records and parental interviews.
- Cluster analysis to define clinical profiles; statistical analysis for parameter comparisons.
Main Results
- SCD patients showed a mean age of 7.59 years, with female predominance and high rural residence (77.3%).
- Parental consanguinity was reported in 54.6% of cases.
- Three clinical profiles emerged: mild anemia, recurrent vaso-occlusive crises (VOC), and acute severe anemia with infections. Higher fetal hemoglobin levels correlated with protection against acute complications and reduced transfusion needs.
Conclusions
- SCD poses a significant health burden in the studied Moroccan region.
- Clinical heterogeneity necessitates tailored management approaches.
- Enhanced nationwide strategies including awareness, education, genetic counseling, and screening are vital for improving patient outcomes.
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