Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.6K
The Parathyroid Glands00:59

The Parathyroid Glands

4.2K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
4.2K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

5.7K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
5.7K
Bone Remodeling01:40

Bone Remodeling

40.2K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.2K
Bone Disorders01:29

Bone Disorders

5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
What is the Skeletal System?01:02

What is the Skeletal System?

56.5K
Overview
56.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regenerative therapies in rehabilitation with interfaces with occupational medicine, geriatrics, and oncology: the example of extracorporeal shock wave therapy.

Wiener medizinische Wochenschrift (1946)·2026
Same author

Effect of the JAK Inhibitor Baricitinib on Cytokine Production and Bone Properties in a Mouse Model of Accelerated Aging.

International journal of molecular sciences·2026
Same author

Investigating the risk of obesity in European night shift workers: a study protocol for cross-sectional and mechanistic studies in the SHIFT2HEALTH Project.

Obesity facts·2026
Same author

FES-Cycling at the Cybathlon 2024: assessing accuracy of power-pedals for low power output in a virtual race scenario.

Journal of neuroengineering and rehabilitation·2026
Same author

[Regenerative therapies with interfaces between rehabilitation, working life, and geriatrics-example of extracorporeal shock wave therapy].

Orthopadie (Heidelberg, Germany)·2026
Same author

Towards integrated people-centred health services: patient-reported experiences of post-COVID care in Austria.

Wiener medizinische Wochenschrift (1946)·2026
Same journal

Systematic review of clinical evidence for Kneipp medicine.

Wiener klinische Wochenschrift·2026
Same journal

Pelvic resections in primary sarcomas : Surgical outcomes and survival analysis of 75 patients.

Wiener klinische Wochenschrift·2026
Same journal

Jungmediziner*innen am Start: 11. Workshop für den medizinischen Nachwuchs.

Wiener klinische Wochenschrift·2026
Same journal

Stellungnahme der ÖGP zur geplanten Gesetzesnovelle zum Nichtraucherschutzgesetz.

Wiener klinische Wochenschrift·2026
Same journal

MUW researcher of the month: Dr. Moritz Schaefer.

Wiener klinische Wochenschrift·2026
Same journal

Alopecia areata: current concepts.

Wiener klinische Wochenschrift·2026
See all related articles

Related Experiment Video

Updated: Jan 6, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.3K

Bone metabolism in primary hyperparathyroidism.

Katharina Kerschan-Schindl1,2, Katharina Gelles3, Maria Butylina3

  • 1Department of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of Vienna, Vienna, Austria. Katharina.Kerschan-Schindl@meduniwien.ac.at.

Wiener Klinische Wochenschrift
|December 2, 2025
PubMed
Summary
This summary is machine-generated.

Primary hyperparathyroidism, a common endocrine disorder, disrupts bone metabolism, increasing resorption and fracture risk. Surgery effectively normalizes bone turnover and reduces fracture risk.

Keywords:
Bone mineral densityBone turnover markerFracture riskOsteitis fibrisa cysticaTherapy

More Related Videos

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

15.2K
Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
14:55

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Published on: June 24, 2018

9.6K

Related Experiment Videos

Last Updated: Jan 6, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

2.3K
Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

15.2K
Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
14:55

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Published on: June 24, 2018

9.6K

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Skeletal Health

Background:

  • Primary hyperparathyroidism is a prevalent endocrine disorder impacting multiple organ systems.
  • Excess parathyroid hormone secretion significantly affects bone metabolism.

Purpose of the Study:

  • To review and discuss the alterations in bone metabolism associated with primary hyperparathyroidism.
  • To highlight the impact of parathyroid hormone on bone resorption and bone mineral density.

Main Methods:

  • Literature review focusing on bone metabolism in primary hyperparathyroidism.
  • Discussion of the effects of parathyroid hormone on bone remodeling.
  • Analysis of surgical outcomes on bone turnover and fracture risk.

Main Results:

  • Excessive parathyroid hormone leads to increased bone resorption and decreased bone mineral density.
  • Compromised bone quality and elevated fracture risk are consequences of the disorder.
  • Surgical intervention normalizes bone turnover and decreases fracture risk.

Conclusions:

  • Primary hyperparathyroidism significantly impairs bone health through enhanced resorption.
  • Surgery offers a definitive solution for normalizing bone metabolism and mitigating fracture risk.
  • Severe bone manifestations like osteitis fibrosa cystica are now rare due to timely interventions.