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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Bone metabolism in primary hyperparathyroidism
Katharina Kerschan-Schindl1,2, Katharina Gelles3, Maria Butylina3
1Department of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of Vienna, Vienna, Austria. Katharina.Kerschan-Schindl@meduniwien.ac.at.
None:
Primary hyperparathyroidism is a frequent endocrine disorder that affects various organ systems. In this review we present and discuss alterations of bone metabolism in primary hyperparathyroidism. Excessive secretion of parathyroid hormone results in increased bone remodelling with an excess of bone resorption. Consequently, bone mineral density declines, bone quality is compromised and fracture risk increases.Successful surgery for hyperparathyroidism results in a normalization of bone turnover and a decrease of fracture risk. Osteitis fibrosa cystica, a severe bone manifestation of hyperparathyroidism, is observed rarely today.
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