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Updated: Jan 6, 2026

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
Published on: February 3, 2015
Clinical Translation of Antibody Positron Emission Tomography for Cancer Imaging
Youngho Seo1,2,3,4, Robert R Flavell1,2,5
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California.
Abstract:
Hepatocellular carcinoma (HCC) lacks precise and noninvasive diagnostic tools. To address this, a new positron emission tomography (PET) radiotracer, [68Ga]Ga-XH-06, was developed. It uses an antibody fragment to target glypican-3 (GPC3), a highly specific biomarker, successfully visualizing GPC3 expressions in patients with HCC, potentially meeting an important unmet need. See related article by Lin et al., p. 550.
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