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Related Experiment Video

Updated: Jan 9, 2026

Rapid Model to Evaluate the Anti-Obesity Potential of a Combination of Syzygium aromaticum Clove and Cuminun cyminum Cumin on C57BL6/j Mice Fed High-Fat Diet
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Sumac (Rhus coriaria L.) and Human Metabolic Health: A Systematic Review and Meta-Analysis.

Ali Jafari1,2, Bahare ParsiNezhad3, Minoo AhmadianMoghaddam4

  • 1Student Research Committee, Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Endocrinology, Diabetes & Metabolism
|December 2, 2025
PubMed
Summary

Sumac supplementation significantly improved lipid profiles and glycemic control in individuals. While not impacting inflammatory markers, these findings suggest potential cardiovascular benefits from regular Sumac use.

Keywords:
anthropometric factorglycemic profilelipid profilemetabolic factormeta‐analysissumac

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Area of Science:

  • Phytochemistry
  • Nutritional Science
  • Cardiovascular Health

Background:

  • Rhus coriaria L. (Sumac) is a spice rich in phytochemicals like flavonoids and polyphenols.
  • Sumac may offer benefits for cardiovascular disease risk factors.
  • This study systematically reviews Sumac's impact on cardiovascular health indicators.

Purpose of the Study:

  • To assess Sumac supplementation's effects on cardiovascular disease risk factors.
  • To analyze anthropometric measures, glycemic profile, inflammatory markers, and lipid profile.
  • To explore dose-response relationships and optimal supplementation duration.

Main Methods:

  • A systematic review and meta-analysis of randomized clinical trials up to March 2025.
  • Searches conducted across major databases (PubMed, Scopus, Web of Science, CENTRAL, EMBASE).
  • Cochrane risk-of-bias tool used for quality assessment; random-effects model for meta-analysis.

Main Results:

  • Fifteen trials involving 917 participants were analyzed (4-12 weeks intervention).
  • Sumac supplementation significantly improved glycemic and lipid profiles.
  • No significant effects observed on anthropometric measures or inflammatory markers.

Conclusions:

  • Sumac supplementation demonstrates potential benefits for cardiovascular health by improving lipid and glycemic parameters.
  • Further research may be needed to explore effects on inflammatory markers.
  • Findings suggest Sumac as a potential dietary intervention for managing cardiovascular risk factors.