Related Experiment Video
Updated: Jan 9, 2026
08:30
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
Published on: March 12, 2016
13.5K
Antifibrotics in glaucoma surgery: current practices and future directions
Christopher Santilli1, Huda Sheheitli
1Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA.
Current Opinion in Ophthalmology
|December 2, 2025
Summary
Mitomycin-C is the standard antifibrotic for glaucoma surgery, but newer agents are emerging. These novel antifibrotics show promise with similar efficacy and improved safety profiles, potentially transforming surgical practices.
Area of Science:
- Ophthalmology
- Surgical Innovation
- Pharmacology
Background:
- Glaucoma surgery aims to reduce intraocular pressure.
- Fibrosis is a major cause of surgical failure after glaucoma procedures.
- Antifibrotic agents are crucial for enhancing surgical outcomes.
Purpose of the Study:
- To review current antifibrotic agents in glaucoma surgery.
- To discuss novel antifibrotic agents in development.
- To highlight potential changes to the standard of care.
Main Methods:
- Literature review of antifibrotic agents.
- Analysis of agents in clinical trials and use.
- Comparison of efficacy and side effect profiles.
Main Results:
- Mitomycin-C (MMC) is the most utilized antifibrotic, with expanding applications.
- MMC toxicity drives innovation for newer agents.
- Bevacizumab, sodium hyaluronate, and matrix metalloproteinases show comparable success to MMC.
- Numerous other antifibrotics are under investigation with varied outcomes.
Conclusions:
- Mitomycin-C remains the gold standard for glaucoma surgery.
- Emerging antifibrotic agents offer potentially safer profiles and comparable efficacy.
- Newer agents may significantly alter future glaucoma surgical practices.
Related Concept Videos
01:27Open Angle Glaucoma: Treatment
934
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
934
01:28Angle Closure Glaucoma: Treatment
1.1K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.1K
01:25Glaucoma: Overview
1.2K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.2K