Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Next-generation Sequencing03:00

Next-generation Sequencing

97.6K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
97.6K
Genomics02:02

Genomics

39.6K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.6K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

6.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.8K
Sanger Sequencing01:57

Sanger Sequencing

772.9K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
772.9K
Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

12.5K
In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...
12.5K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reference intervals reimagined with IRIS for earlier detection and better disease monitoring.

Scientific reports·2026
Same author

Regulating complexity in AI-enabled omics and multi-omics technologies for precision medicine.

NPJ digital medicine·2026
Same author

From ageing clocks to human digital twins in personalising healthcare through biological age analysis.

NPJ digital medicine·2025
Same author

Cohort profile: The Belgian I AM frontier prospective cohort study for comprehensive health outcome exploration.

PloS one·2025
Same author

Dynamic star allele definitions in Pharmacogenomics: impact on diplotype calls, Phenotype predictions and statin therapy recommendations.

Frontiers in pharmacology·2025
Same author

Language as a barrier to colorectal cancer screening in flanders: an ecological study.

Archives of public health = Archives belges de sante publique·2025

Related Experiment Video

Updated: Jan 9, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

34.5K

Genomic sequence data sharing for clinical practice: A scoping review.

Elias Crum1, Ruben Taelman2, Bart Buelens3

  • 1Flemish Institute for Technological Research (VITO), Technologiehuis, Industriezone Vlasmeer 5, 2400 Mol, Belgium; IDLab, Department of Electronics and Information Systems, Ghent University - imec, Technologiepark-Zwijnaarde 122, Floor 7, 9052 Gent, Belgium.

Computers in Biology and Medicine
|December 2, 2025
PubMed
Summary

Sharing patient genomic data is crucial for genomic medicine. Current approaches exist but face scalability and infrastructure challenges, hindering widespread adoption and requiring unified standards for progress.

Keywords:
Clinical genomicsData sharingGenomic data privacyHuman genome dataImplementations

More Related Videos

Generating Whole Bacterial Genomes from Clinical Samples using a Target Enrichment Workflow
10:44

Generating Whole Bacterial Genomes from Clinical Samples using a Target Enrichment Workflow

Published on: August 15, 2025

1.0K
Novel Sequence Discovery by Subtractive Genomics
09:40

Novel Sequence Discovery by Subtractive Genomics

Published on: January 25, 2019

9.1K

Related Experiment Videos

Last Updated: Jan 9, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

34.5K
Generating Whole Bacterial Genomes from Clinical Samples using a Target Enrichment Workflow
10:44

Generating Whole Bacterial Genomes from Clinical Samples using a Target Enrichment Workflow

Published on: August 15, 2025

1.0K
Novel Sequence Discovery by Subtractive Genomics
09:40

Novel Sequence Discovery by Subtractive Genomics

Published on: January 25, 2019

9.1K

Area of Science:

  • Genomic Medicine
  • Bioinformatics
  • Health Informatics

Background:

  • Scaling genomic medicine is hindered by difficulties in sharing patient genomic data.
  • Existing genomic data sharing approaches, infrastructure, and guidelines require comprehensive assessment.
  • Incorporating insights from national initiatives and industry is vital for broad relevance.

Purpose of the Study:

  • To assess current genomic data sharing approaches, infrastructure, and guidelines.
  • To identify challenges and barriers in genomic data sharing.
  • To promote actionable standards and future directions for genomic data sharing.

Main Methods:

  • A scoping review framework (Arksey & O'Malley) was employed.
  • Analysis included peer-reviewed articles, gray literature, national genomics initiatives, and corporate strategies.
  • Data were categorized based on clinical care, research, national initiatives, and corporate contexts.

Main Results:

  • 55 studies were identified, with 15 clinical sharing implementations, 9 research frameworks, and 13 ethical/legal guidelines.
  • Analysis of 57 national genome initiatives and 20 genomics companies revealed existing implementations but limited scalability.
  • Key challenges identified include scalability, infrastructure differences (clinical vs. research), and genomic medicine maturity.

Conclusions:

  • Clinical genomic data sharing implementations are present but not widely adopted due to scalability issues.
  • Addressing infrastructure disparities and advancing genomic medicine maturity are critical for progress.
  • Four recommended steps aim to foster a unified approach to genomic data sharing and catalyze innovation.