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Rapid quantitative susceptibility mapping using single-shot echo planar time-resolved imaging.

Haoran Bai1,2, Ke Dai1, Zhenghao Li1

  • 1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, People's Republic of China.

Physics in Medicine and Biology
|December 2, 2025
PubMed
Summary
This summary is machine-generated.

Single-shot echo planar time-resolved imaging (EPTI) offers distortion-free, multi-contrast imaging for rapid quantitative susceptibility mapping (QSM). This advanced method overcomes limitations of echo-planar imaging (EPI), improving anatomical fidelity and reducing artifacts.

Keywords:
echo planar imagingquantitative susceptibility mappingtime-resolved imaging

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Area of Science:

  • Medical Imaging
  • Biophysics
  • Neuroimaging

Background:

  • Echo-planar imaging (EPI) enables fast quantitative susceptibility mapping (QSM) but is prone to artifacts from magnetic field inhomogeneity and air-tissue interfaces.
  • These artifacts limit the accuracy and reliability of EPI-based QSM, especially in challenging brain regions.

Purpose of the Study:

  • Introduce single-shot echo planar time-resolved imaging (EPTI) as a novel technique for rapid, distortion-free, and multi-contrast quantitative susceptibility mapping (QSM).
  • Evaluate the performance of EPTI-QSM against established methods like 3D gradient echo (GRE) and single-shot EPI.

Main Methods:

  • Employed a zig-zag ky-t sampling trajectory in 2D single-shot EPTI.
  • Utilized locally low-rank subspace reconstruction with B0 updating for distortion-free multi-echo image generation from undersampled data.
  • Compared EPTI-QSM with 3D GRE and single-shot EPI using a 4-step masking procedure.

Main Results:

  • EPTI-QSM exhibited superior anatomical fidelity and reduced susceptibility artifacts compared to single-shot EPI, with reliable brain coverage.
  • Multi-echo EPTI data (10-30 ms echo times) enhanced susceptibility quantification and mitigated signal dropouts near air-tissue interfaces.
  • EPTI provided distortion-free structural images and improved contrast over 3D GRE, aiding anatomical visualization.

Conclusions:

  • Single-shot EPTI is a promising technique for rapid and robust quantitative susceptibility mapping (QSM).
  • EPTI overcomes EPI limitations, offering distortion-free, multi-contrast imaging for improved QSM applications.
  • This method represents a significant advancement for neuroimaging requiring accurate susceptibility quantification.