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Social Deprivation as a Risk Factor for Manipulation Under Anesthesia Following Total Knee Arthroplasty
Uma Balachandran1, Brocha Z Stern1,2, Suraj Dhanjani1
1Leni and Peter W. May Department of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, United States.
The Journal of Knee Surgery
|December 2, 2025
Summary
Social deprivation may paradoxically lower manipulation under anesthesia (MUA) rates after total knee arthroplasty (TKA). More research is needed to understand if this reflects better outcomes or challenges in accessing postoperative care for socially deprived patients.
Area of Science:
- Orthopedic Surgery
- Health Services Research
- Social Determinants of Health
Background:
- Manipulation under anesthesia (MUA) is a complication following total knee arthroplasty (TKA).
- Previous studies indicate Black patients and socially deprived individuals face higher MUA risks.
- Understanding the impact of social deprivation on TKA outcomes is crucial for health equity.
Purpose of the Study:
- To investigate the association between area-level and person-level social deprivation and the odds of MUA within one year after TKA.
- To analyze how the Social Deprivation Index (SDI) and dual Medicare/Medicaid eligibility relate to MUA risk.
Main Methods:
- Retrospective cohort study of fee-for-service Medicare beneficiaries aged 65+ undergoing primary elective TKA (2016-2020).
- Area-level social deprivation measured by county-level Social Deprivation Index (SDI).
- Person-level social deprivation assessed by dual Medicare/Medicaid eligibility; analyzed using mixed-effects generalized linear models.
Main Results:
- The most socially deprived quintile showed significantly lower odds of MUA compared to less deprived quintiles (ORs ranging from 0.70 to 0.77).
- Dual Medicare/Medicaid eligibility was not significantly associated with MUA.
- No significant differences in MUA were found for the person-level deprivation indicator.
Conclusions:
- Higher social deprivation at the area level was unexpectedly associated with lower odds of MUA after TKA.
- This finding may suggest potential barriers in accessing postoperative care for highly deprived populations, rather than improved outcomes.
- Further investigation is warranted to elucidate the complex relationship between social deprivation and TKA outcomes.

