Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical Pig Organ Transplantation: What Have We Learned So Far?

Xenotransplantation·2026

Same author

Advancing lupus nephritis research through multi-omics and predictive modeling.

Innate immunity·2026

Same author

Integrative single-cell and spatial transcriptomics analysis reveals FLAD1 as a regulator of the immune microenvironment in hepatocellular carcinoma.

Frontiers in immunology·2025

Same author

The single-cell revolution in transplantation: high-resolution mapping of graft rejection, tolerance, and injury.

Frontiers in immunology·2025

Same author

Targeting macrophages and ion homeostasis in T2D: new genes and therapeutic pathways identified.

Frontiers in immunology·2025

Same author

Mapping the role of cytokine signaling at single-cell and structural resolution in uveal melanoma.

Genes and immunity·2025

Search research articles

Related Experiment Video

Updated: Jan 9, 2026

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

Mapping the Microenvironment: How Spatial-Omics Is Advancing the Understanding of Allograft Fate.

Lisha Mou^1,2, Zuhui Pu^2,3

¹Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, Shenzhen, China.

Clinical Transplantation

|December 2, 2025

Summary

Spatial omics technologies reveal complex cellular interactions in organ transplants, improving understanding of rejection and guiding precision immunosuppression for better long-term success.

Keywords:

allograft rejection organ transplantation precision medicine spatial proteomics spatial transcriptomics transplant immunology

More Related Videos

Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research

Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research

Published on: April 26, 2019

A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice

A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice

Published on: January 23, 2016

Related Experiment Videos

Last Updated: Jan 9, 2026

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research

Modified Heterotopic Hindlimb Osteomyocutaneous Flap Model in the Rat for Translational Vascularized Composite Allotransplantation Research

Published on: April 26, 2019

A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice

A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice

Published on: January 23, 2016

Area of Science:

Transplant immunology and pathology
Molecular biology and omics technologies
Biomedical engineering and instrumentation

Background:

Solid organ transplantation success is limited by rejection and pathology.
Traditional methods lack spatial resolution to analyze allograft microenvironments.
Spatial omics technologies offer new molecular analysis capabilities within intact tissue.

Purpose of the Study:

Review major spatial transcriptomic and proteomic platforms.
Synthesize key findings from spatial omics in kidney, lung, liver, and heart transplantation.
Explore applications in understanding transplant rejection, dysfunction, injury, and tolerance.

Main Methods:

Overview of sequencing-based spatial omics technologies.
Discussion of imaging-based spatial omics platforms.
Highlighting high-plex protein imaging technologies.

Main Results:

Spatial omics resolve rejection heterogeneity (T-cell mediated and antibody-mediated rejection (ABMR)).
Elucidation of chronic allograft dysfunction and ischemia-reperfusion injury (IRI) mechanisms.
Delineation of immune microenvironments in operational tolerance (OT) and tertiary lymphoid structures (TLS).

Conclusions:

Spatial omics refine understanding of transplant pathology from diffuse inflammation to specific pathogenic microenvironments.
These technologies pave the way for precision immunosuppression strategies.
Future development of digital biopsies may guide individualized transplant therapies.