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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Neuroendocrine timekeepers: changes in normal and premature aging.

Maria Petricǎ1, Marisa Ferreira-Marques2, Rodrigo F N Ribeiro3

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|December 2, 2025
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Summary

Aging impairs the hypothalamus, affecting circadian rhythms and metabolism. Understanding these changes, including insights from laminopathies, may reveal interventions like chronotherapy to promote healthy aging.

Keywords:
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Area of Science:

  • Neuroendocrinology
  • Chronobiology
  • Gerontology

Background:

  • The hypothalamus regulates critical functions like circadian rhythms, metabolism, and endocrine signaling, maintaining homeostasis.
  • Aging significantly impairs hypothalamic function, contributing to metabolic disorders, sleep disturbances, and increased disease risk.
  • Laminopathies, characterized by premature aging, demonstrate severe neuroendocrine and circadian rhythm dysfunction, offering a model for hypothalamic aging.

Purpose of the Study:

  • To review molecular and physiological insights into hypothalamic aging and circadian misalignment.
  • To explore the role of neuroendocrine crosstalk in regulating health span and life span.
  • To highlight potential interventions for mitigating hypothalamic aging and promoting healthy aging.

Main Methods:

  • Literature review of molecular and physiological studies on hypothalamic aging.
  • Analysis of data from studies on laminopathies and their impact on neuroendocrine and circadian systems.
  • Synthesis of information on interventions such as chronotherapy and caloric restriction.

Main Results:

  • Aging disrupts hypothalamic regulation of circadian rhythms and metabolism.
  • Neuroendocrine and circadian dysfunctions are prominent features of both aging and laminopathies.
  • Interventions targeting hypothalamic pathways show promise for healthy aging.

Conclusions:

  • The hypothalamus is central to aging processes, with its dysfunction impacting health span.
  • Neuroendocrine crosstalk is critical for age-related physiological changes.
  • Chronotherapy and caloric restriction are potential strategies to counteract hypothalamic aging.