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Menopause and Common Dermatoses: A Systematic Review.

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Menopause significantly impacts skin conditions like hair loss and psoriasis, while its effects on acne and rosacea are generally positive. Menopausal hormone therapy (MHT) shows variable results and requires further research.

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Area of Science:

  • Dermatology and endocrinology research.
  • Investigating the intersection of women's health and skin conditions.

Background:

  • Menopause, a natural decline in estrogen, affects skin and mucosal health.
  • The precise impact of menopause and menopausal hormone therapy (MHT) on chronic skin diseases is not fully understood.

Purpose of the Study:

  • To explore the associations between menopause, MHT, and common dermatological conditions.
  • To synthesize current evidence on how menopausal status influences various skin disorders.

Main Methods:

  • Systematic review of PubMed, Embase, and Web of Science databases up to September 2024.
  • Inclusion of 40 studies examining menopause/MHT effects on alopecia, psoriasis, acne, rosacea, melasma, and hidradenitis suppurativa (HS).
  • Extraction and synthesis of data on study design, population, hormonal status, and dermatological outcomes.

Main Results:

  • Postmenopausal alopecia, especially frontal fibrosing alopecia (FFA) and female pattern hair loss (FPHL), showed the strongest link to menopause.
  • Psoriasis often persisted or worsened post-menopause; acne and rosacea generally improved.
  • Melasma outcomes were mixed, and HS responses were inconsistent. MHT was linked to increased FFA and rosacea risk, with variable findings for other conditions.

Conclusions:

  • Menopause influences the development and progression of several chronic skin diseases.
  • Evidence regarding MHT's impact is limited and inconsistent, often based on older formulations.
  • Further dermatology-focused research with diverse populations and current MHT is crucial for personalized patient care.