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Related Experiment Video

Updated: Jan 9, 2026

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Interventions for Treating Actinic Cheilitis: A Systematic Review.

Alejandra Fernández Herranz1, José González-Serrano1, Vito Carlo Alberto Caponio1,2

  • 1ORALMED Research Group, Department of Dental Clinical Specialties, School of Dentistry, Complutense University, Madrid, Spain.

Oral Diseases
|December 2, 2025
PubMed
Summary

The optimal treatment for actinic cheilitis (AC) remains undetermined due to study limitations. Methyl aminolevulinate plus daylight photodynamic therapy (PDT) and CO2 laser showed promise for clearing AC lesions.

Keywords:
actinic cheilitisinterventionoral potentially malignant disordersprecancerous conditionstreatment

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Area of Science:

  • Dermatology
  • Oral Medicine
  • Oncology

Background:

  • Actinic cheilitis (AC) is a sun-induced oral potentially malignant disorder.
  • Optimal treatment strategies for AC are not yet established.
  • This review addresses the need for evidence-based AC treatment guidelines.

Purpose of the Study:

  • To systematically review and evaluate the therapeutic efficacy of various treatments for actinic cheilitis (AC).
  • To identify the most effective interventions for managing this oral potentially malignant disorder.

Main Methods:

  • A systematic review of Randomized Clinical Trials (RCTs) comparing AC treatments against placebo or other interventions.
  • Comprehensive literature search across major databases (PubMed, Cochrane, etc.) conducted in February 2025.
  • Risk of bias assessment using RoB2 tool and qualitative synthesis of clinical outcomes.

Main Results:

  • Eight RCTs with 230 participants were analyzed.
  • Methyl aminolevulinate (MAL) plus daylight photodynamic therapy (PDT), CO2 laser, and electrodessication showed high 3-month clearance rates.
  • CO2 laser demonstrated sustained effectiveness at 6 months, but high risk of bias in most trials limits definitive conclusions.

Conclusions:

  • The most effective treatment for actinic cheilitis (AC) cannot be definitively determined due to significant study limitations.
  • Future research requires improved methodology, standardized therapies, and long-term follow-up to assess recurrence and malignant transformation rates.