Risk Factors of Subchorionic Hematoma Under Assisted Reproductive Technology
Xi Yi1, Zhaxicuo2, Dongmei Tian1
1School of Medical and Life Sciences/Reproductive & Women-Children Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
The Journal of Obstetrics and Gynaecology Research
|December 3, 2025
Summary
Assisted reproductive technology (ART) increases subchorionic hematoma (SCH) risk due to factors like hormone levels and embryo transfer procedures. Understanding these risks aids in managing SCH for better pregnancy outcomes.
Area of Science:
- Reproductive Medicine
- Obstetrics
- Pregnancy Complications
Background:
- Subchorionic hematoma (SCH) incidence rises with assisted reproductive technology (ART) use.
- SCH poses significant risks to maternal and fetal health.
Purpose of the Study:
- To systematically review the pathogenesis and risk factors of SCH in ART.
- To explore the relationship between ART and SCH occurrence.
Main Methods:
- PubMed database search for "subchorionic hematoma" (1975-2025).
- Inclusion of 50 studies from 278 retrieved articles.
Main Results:
- ART, particularly IVF, is a central risk factor for SCH.
- High estrogen/progesterone, specific embryo transfer types, low blastocyst grading, PCOS, tubal hydrocele, and low-dose aspirin increase SCH risk.
- ART procedures may disrupt endometrial angiogenesis and placental development, leading to hematoma.
Conclusions:
- Provides evidence for clinical screening and management of SCH in ART.
- Highlights the need for further research into risk factor mechanisms.
- Aims to optimize pregnancy outcomes for ART patients.
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