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Root coverage using recombinant human fibroblast growth factor-2 treated connective tissue graft: Case studies.
Guo-Liang Cheng1, Satoru Urano2,3, Yu-Chang Wu1
1Division of Periodontology, The Ohio State University College of Dentistry, Columbus, Ohio, USA.
Clinical Advances in Periodontics
|December 3, 2025
Summary
Connective tissue grafts (CTG) combined with recombinant human fibroblast growth factor-2 (rhFGF-2) effectively treated severe gum recession after orthodontics. This approach achieved nearly 100% root coverage, improved aesthetics, and enhanced periodontal health.
Area of Science:
- Periodontology
- Regenerative Medicine
- Oral Surgery
Background:
- Gingival recession is a common complication of orthodontic treatment, especially with thin gingival phenotypes.
- Severe recession can lead to esthetic concerns, tooth sensitivity, and discomfort.
- Connective tissue grafts (CTG) are standard for root coverage but have limitations in severe cases.
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