Effect of finerenone on proteinuria reduction in IgA nephropathy
Guizhen Yu1, Meifang Wang1, Xue Zhang1
1Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Institute of Nephrology, Zhejiang Clinical Research Center of Kidney and Urinary System Disease, Zhejiang University School of Medicine, Hangzhou, China.
Background:
Recent studies have suggested a protective effect of finerenone on renal function and reduced the risk of cardiovascular events in patients with CKD and type 2 diabetes. However, its role in IgA nephropathy remains unknown. This study aimed to evaluate its efficacy against IgA nephropathy.
Methods:
A total of 18 IgAN patients with full supportive therapy, including RAS blockade as much as allowed or tolerated, blood pressure control and steroids and/or other immunosuppressive agents. Analyzed at 2, 4, 6 and 8 months after finerenone therapy.
Results:
Eighteen IgA nephropathy patients were enrolled in this study, after 6.78 ± 3.47 months follow-up, a significant reduction was observed in protein-to-creatinine ratio with a 28.48% (p = 0.003), 13.12% (p = 0.17), 31.33% (p = 0.003), 39.69% (p = 0.02), respectively, at 2, 4, 6 and 8 months of treatment with finerenone compared to baseline. The eGFR was relatively stable during follow-up.
Conclusions:
The protein-to-creatinine ratio was significantly reduced after finerenone treatment in IgA nephropathy patients with full supportive therapy, and the eGFR was stable during follow-up.
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