Electroactive Copper-Cyanurate Coordination Polymer for Thiosulfate Monitoring in Biological Fluids

Area of Science:

• Electrochemistry
• Materials Science
• Toxicology

Background:

• Thiosulfate detection is crucial for cyanide poisoning treatment and environmental monitoring.
• Existing methods for thiosulfate detection may lack sensitivity, selectivity, or noninvasiveness.

Purpose of the Study:

• To develop a highly sensitive and selective electrochemical sensor for thiosulfate detection.
• To engineer an electroactive copper-cyanurate (Cu-CYA) coordination polymer for this purpose.

Main Methods:

• Synthesis of Cu-CYA coordination polymer via self-assembly.
• Fabrication of a Cu-CYA/graphite pencil electrode (GPE) sensor.
• Electrochemical characterization using cyclic voltammetry and differential pulse voltammetry.

Main Results:

• The Cu-CYA/GPE sensor showed a linear response to thiosulfate from 100 to 500 nM.
• Achieved high sensitivity (2.94 µA cm⁻² nM⁻¹) and a low limit of detection (0.32 nM).
• Demonstrated excellent selectivity, long-term stability (93.3% after 30 days), and high recovery (97.5%) in human saliva.

Conclusions:

• Cu-CYA is a promising material for developing robust electrochemical sensors.
• The developed sensor offers a reliable platform for thiosulfate monitoring in clinical toxicology and environmental safety.
• This technology holds potential for portable diagnostic applications.