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Published on: June 20, 2025
409
Migrasomes in Ischemic Stroke: Molecular Landscape and Pathophysiological Impact
Huifen Zhou1,2, Yingying Zhang1, Peng Zhou1
1School of Basic Medical Sciences, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou, Zhejiang, 310053, P. R. China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|December 3, 2025
Summary
Migrasomes, small vesicles released by immune cells, worsen ischemic stroke (IS) injury and inflammation. Targeting these migrasomes may offer new therapeutic strategies for stroke patients.
Area of Science:
- Neuroscience
- Immunology
- Biochemistry
Background:
- Ischemic stroke (IS) triggers systemic responses beyond the brain.
- Understanding these systemic effects is crucial for effective stroke treatment.
Purpose of the Study:
- To investigate the systemic molecular changes following ischemic stroke.
- To identify novel molecular players involved in stroke pathophysiology.
Main Methods:
- Integrated multi-omics (proteomics, metabolomics, lipidomics) on IS patient samples.
- Proteomic profiling of plasma and brain migrasomes.
- Functional assays using migrasomes in an IS model.
Main Results:
- Identified distinct molecular subtypes in IS patients related to immune, oxidative, and metabolic dysregulation.
- Elevated migrasome levels were found in IS patients and mouse models.
- Migrasomes are enriched in complement, coagulation, and cholesterol pathways.
- Peripheral immune cell-derived migrasomes worsened ischemic injury and inflammation.
Conclusions:
- Migrasomes are key contributors to ischemic stroke pathophysiology.
- Migrasomes represent a promising therapeutic target for stroke intervention.
