Natural, Engineered, and Hybrid Platelet Membrane-Based Nanotherapeutics for Inflammatory Diseases

Area of Science:

• Nanomedicine
• Biomaterials Science
• Immunology

Background:

• Platelet membrane nanotherapeutics represent an advanced biomimetic strategy in nanomedicine.
• These platforms combine the natural biointerfacing capabilities of platelets with engineered nanoparticle cores.

Purpose of the Study:

• To systematically review recent advances in the design and application of platelet membrane-based nanotherapeutics.
• To categorize these nanotherapeutics into distinct platforms based on membrane origin and engineering.
• To highlight their therapeutic efficacy across a range of inflammatory conditions.

Main Methods:

• Review of recent scientific literature on platelet membrane nanotherapeutics.
• Categorization of nanotherapeutic platforms: natural platelet membranes, engineered platelet membranes, and hybrid membranes.
• Emphasis on therapeutic applications in inflammatory diseases and the tumor microenvironment.

Main Results:

• Nanotherapeutics derived from natural, engineered, or hybrid platelet membranes demonstrate significant potential.
• These platforms exhibit enhanced properties like long circulation, immune evasion, and targeted delivery to inflamed tissues.
• Therapeutic efficacy is shown in atherosclerosis, ischemic injuries, rheumatoid arthritis, infections, and tumor inflammation.

Conclusions:

• Platelet membrane nanotherapeutics offer a promising avenue for precision medicine in treating inflammatory diseases.
• Further development is needed to address translational challenges and optimize future applications.
• The review provides a critical perspective on the future development of this technology.