A Prospective Study on the Efficacy and Safety of the Bipolar Radiofrequency with Multi-Channel and Vacuum-Assisted...

The periorbital region is highly susceptible to aging, manifesting as wrinkles, skin laxity, and under-eye bags due to collagen loss and fat displacement. Vacuum-assisted multi-frequency bipolar radiofrequency (RF) offers precise energy delivery, effectively stimulating collagen remodeling while ensuring safety and patient comfort.

This study aimed to evaluate the efficacy and safety of a bipolar RF device with channeling optimized RF energy (CORE™) technology and vacuum assistance for periorbital rejuvenation.

A prospective, single-center trial enrolled 28 participants (18-60 years), receiving four treatments at three-week intervals. Efficacy was assessed through Fitzpatrick Wrinkle Scale (FWS), Investigator Global Assessment (IGA) scores, and objective skin parameters (hydration, elasticity, gloss), alongside participant self-assessments. Safety was evaluated via adverse events (AEs) and pain scores (VAS).

Among 22 participants who completed the study, 95.46% achieved ≥25% improvement in FWS scores (mean reduction: -1.55 ± 0.50), with significant wrinkle reduction from the second treatment (p < 0.001). IGA scores showed visible improvement in under-eye bags, while skin hydration and elasticity increased. About 90.91% of participants reported high satisfaction, and 91.3% rated pain ≤1, with no AEs reported. The total observation period was approximately 12 weeks, including four treatment sessions and a three-week follow-up after the final session.

Bipolar RF treatment with CORE technology and vacuum assistance is a safe and effective non-invasive modality for improving periorbital wrinkles and under-eye bags. By promoting collagen remodeling and skin tightening, this technology offers significant clinical and aesthetic benefits with minimal discomfort and no adverse events.