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Related Experiment Video

Updated: Jan 9, 2026

Effective Oral RNA Interference RNAi Administration to Adult Anopheles gambiae Mosquitoes

Effective Oral RNA Interference RNAi Administration to Adult Anopheles gambiae Mosquitoes

Published on: March 1, 2022

Sickle-trait hemoglobin does not influence Anopheles biting rates.

Christine F Markwalter¹, Emmah Kimachas², Erastus Kirwa²

¹Duke Global Health Institute, Duke University, Durham, NC, USA.

Medrxiv : the Preprint Server for Health Sciences

|December 3, 2025

Summary

This summary is machine-generated.

Children with sickle cell trait (HbAS) have malaria protection. This study found sickle cell trait does not reduce exposure to infectious mosquito bites, suggesting other resistance mechanisms are at play.

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Published on: January 12, 2017

Area of Science:

Malariology
Genetics
Epidemiology

Background:

Sickle cell trait (HbAS) confers protection against severe Plasmodium falciparum malaria.
Mechanisms of this protection are not fully understood, particularly regarding mosquito bite exposure.

Purpose of the Study:

To investigate if sickle cell trait influences exposure to P. falciparum-infected mosquito bites.
To determine individual mosquito biting rates in relation to human beta-globin genotypes.

Main Methods:

A 15-month cohort study in Western Kenya.
Matching mosquito bloodmeals to human hosts using short tandem repeat (STR) genotypes.
Multilevel multivariable modeling to assess mosquito biting behavior based on human beta-globin genotypes (HbAA vs. HbAS).

Main Results:

No significant difference in mosquito biting rates was observed between individuals with HbAA and HbAS genotypes (BRR: 1.23, 95% CI: 0.86 - 1.77).
Individual mosquito biting rates were comparable across different beta-globin genotypes.

Conclusions:

The protective effect of sickle cell trait against severe malaria is unlikely due to reduced exposure to infectious mosquito bites.
Other within-host resistance mechanisms likely contribute to the observed malaria protection in individuals with sickle cell trait.