Materiobiology in the omics era

Area of Science:

• Materiobiology
• Regenerative Medicine
• Biomaterials Science

Background:

• Cellular responses to materials are complex and involve multiple biological levels.
• Understanding these interactions is crucial for developing effective biomaterials.
• Current knowledge gaps exist in precisely defining cellular responses to biomaterials.

Purpose of the Study:

• To review the application of various omics technologies in materiobiology.
• To highlight how omics approaches elucidate cellular responses to biomaterials.
• To discuss the role of multi-omics in advancing regenerative medicine and biomaterial design.

Main Methods:

• Review of single-cell transcriptomics, transcriptomics, RNomics, genomics, proteomics, metabolomics, lipidomics, glycomics, and immunomics.
• Analysis of how these omics technologies reveal cell heterogeneity and regulatory mechanisms.
• Examination of multi-omics strategies in the context of bone organoid construction.

Main Results:

• Omics technologies reveal cell heterogeneity, transcriptional and epigenetic regulation, genetic determinants, metabolic pathways, and immune networks in response to biomaterials.
• Multi-omics approaches facilitate the construction of bone organoids for studying bone development and repair.
• These methods provide insights into lipid and glycan remodeling upon material interaction.

Conclusions:

• Multi-omics technologies are pivotal in driving materiobiology forward.
• These approaches bridge molecular insights with material innovation for precision regenerative medicine.
• The rational design of next-generation biomaterials is supported by omics-driven understanding.