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The Association of Hypertensive Disorders in Pregnancy with Offspring Kidney Function from Adolescence into Young

Jo A Kelly1, Mark C Chapell2, Elizabeth T Jensen2

  • 1Wake Forest University School of Medicine.

Research Square
|December 3, 2025
PubMed

Insights

Hypertensive disorders in pregnancy (HDP) did not show a significant association with offspring kidney function in adolescence or young adulthood among individuals born preterm with very low birth weight. Further research may explore prematurity

Area of Science:

  • Perinatal Medicine
  • Nephrology
  • Developmental Pediatrics

Background:

  • Hypertensive disorders in pregnancy (HDP) are a significant concern affecting maternal and fetal health.
  • Individuals born preterm with very low birth weight (VLBW) may be at increased risk for long-term health complications.
  • Understanding the long-term impact of HDP on offspring kidney function is crucial for this vulnerable population.

Purpose of the Study:

  • To investigate the association between maternal hypertensive disorders in pregnancy (HDP) and the kidney function of offspring born preterm with very low birth weight (VLBW).
  • To assess offspring kidney function in both adolescence and young adulthood.
  • To explore potential mediation effects of adolescent kidney function on the relationship between HDP and young adult kidney function.

Main Methods:

  • Secondary analysis of a prospective cohort study including 213 participants born preterm with VLBW (< 1500 g).
  • Kidney function assessed via estimated glomerular filtration rate (eGFR) and albumin-to-creatinine ratio (ACR) at 14-15 and 19-23 years of age.
  • Multivariable generalized linear models and causal mediation analysis were employed to estimate associations and mediation effects.

Main Results:

  • 37% of participants were exposed to HDP.
  • No significant association was found between HDP exposure and offspring kidney function (eGFR or ACR) in adolescence or young adulthood.
  • No statistically significant causal mediation effect of adolescent kidney function on the HDP-young adulthood kidney function relationship was observed.

Conclusions:

  • Maternal hypertensive disorders in pregnancy (HDP) do not appear to be significantly associated with long-term kidney function in offspring born preterm with very low birth weight (VLBW).
  • Adolescent kidney function does not mediate the potential effects of HDP on young adult kidney function in this cohort.
  • Future research should consider the impact of prematurity severity on offspring kidney function, as HDP is a contributing factor to preterm birth.
Abstract

Keywords:
Pediatric nephrologyorganogenesispediatricspregnancy complications

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