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Updated: Jan 9, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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A Case of Evolving Hepatotoxicity Following Systemic Drug Reaction to Isoniazid-Rifapentine (3HP)

Niels Vizgan1, Jesse Martinez-Kratz1, Chris LaBudde1

  • 1School of Medicine, Tufts University, Boston, Massachusetts, USA.

Case Reports in Hepatology
|December 3, 2025
PubMed

Insights

The 3-month, once-weekly isoniazid plus rifapentine (3HP) regimen for latent tuberculosis infection can cause drug reactions and liver injury. Early recognition and management are crucial for patient safety during this effective TB treatment.

Area of Science:

  • Infectious Diseases
  • Hepatology
  • Pharmacology

Background:

  • The 3-month, once-weekly isoniazid plus rifapentine (3HP) regimen is a preferred treatment for latent tuberculosis infection (LTBI) due to its short duration and high adherence.
  • However, 3HP therapy is linked to potential adverse events, including hepatotoxicity and systemic drug reactions (SDRs).

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