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Htr1b is necessary for normal retinal function in mice.

Solomon E Gibson1,2, Xiaofeng Tao1, Guofu Shen1

  • 1Department of Ophthalmology, Baylor College of Medicine, Houston, TX, United States.

Frontiers in Cellular Neuroscience
|December 3, 2025
PubMed
Summary

The serotonin 5-HT receptor 1B (Htr1b) is crucial for retinal function, regulating visual sensitivity and retinal ganglion cell (RGC) activity. Its absence causes visual deficits, highlighting its role in vision.

Keywords:
5-HT5-HT1B5-hydroxytryptamineretinaretinal ganglion cell (RGC)serotoninserotonin receptor 1B (HTR1B)

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Molecular Biology

Background:

  • Serotonin (5-HT) plays a role in retinal development and function.
  • The specific roles of individual 5-HT receptors in the retina are not well understood.

Purpose of the Study:

  • To investigate the role of serotonin receptor 1B (Htr1b) in retinal function and visual processing.
  • To characterize the contribution of Htr1b to serotonergic signaling in the retina.

Main Methods:

  • RNA sequencing and in situ labeling for Htr1b localization.
  • Histology and SD-OCT for retinal structure assessment.
  • Optomotor tests for visual function.
  • In vivo ERG and ex vivo MEA recordings for retinal function analysis.

Main Results:

  • Htr1b is localized to the inner retina and RGCs.
  • Htr1b knockout mice show deficits in contrast sensitivity and visual acuity.
  • ERG and MEA recordings reveal altered RGC function, including latency delays, reduced sensitivity, and abnormal firing patterns.

Conclusions:

  • Htr1b is essential for normal retinal serotonergic signaling.
  • Htr1b regulates RGC excitability and visual sensitivity.
  • Targeting Htr1b may offer therapeutic potential for visual disorders.